ED95 of Lidocaine 1.0% for Filling the Adductor Canal

NCT02033356 ↗

Phase 2 Completed 40 enrolled Rigshospitalet, Denmark

Non-randomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of this prospective dose finding study is to estimate the minimal effective volume (ED95) for lidocaine 1.0% for filling the adductor canal when placing an adductor canal block. We will apply the Continual Reassessment Method (CRM) for estimating the ED95 and use an MRI scan to evaluate the main objective and ensure spread to the distal part of the adductor canal.

Timeline

Start: 2014-01
Primary completion: 2014-02
Completion: 2014-02

Publications

Jaeger P, Jenstrup MT, Lund J, Siersma V, Brondum V, Hilsted KL, Dahl JB. Optimal volume of local anaesthetic for adductor canal block: using the continual reassessment method to estimate ED95. Br J Anaesth. 2015 Dec;115(6):920-6. doi: 10.1093/bja/aev362.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	5 ml	Other
Subject	Lidocaine	Other / unclassified	10 ml	Other
Subject	Lidocaine	Other / unclassified	15 ml	Other
Subject	Lidocaine	Other / unclassified	20 ml	Other
Subject	Lidocaine	Other / unclassified	25 ml	Other
Subject	Lidocaine	Other / unclassified	30 ml	Other

Indications

No indication recorded.