drugset / Trial / NCT02037711

Intraperitoneal Application of Levobupivacaine During Laparoscopic Surgery in Kids.

NCT02037711

Phase 4 Completed 40 enrolled Cairo University
RandomizedParallel-groupSingle-blind

Summary

Pain after laparoscopic surgery has been associated with surgical manipulations, including intraperitoneal insufflation of carbon dioxide (CO2), resulting in peritoneal stretching, diaphragmatic irritation, changes in intra-abdominal pH, and retention of the insufflated gas in the abdominal cavity after surgery. These effects may result in the irritation of peritoneal nerves causing visceral pain, as commonly reported after laparoscopic procedures in pediatrics. The study hypothesis is that Intraperitoneal local anesthetic (levobupivacaine) instillation can provide pain relief after laparoscopic surgery, but local anesthetic distribution may not always be uniform throughout the peritoneal surface. Many methods were tried for intraperitoneal application of local anesthetics in laparoscopic surgery such as local anesthetic (LA) instillation and LA nebulization. -But these methods are not widely used in pediatrics upon our knowledge

Timeline

Start
2013-05
Primary completion
2013-11
Completion
2013-11

Drugs

EvaluationDrugModalityDoseRoute
Comparator Levobupivacaine Other / unclassified 2 mg/kg Other

Indications

No indication recorded.