drugset / Trial / NCT02047253

Phase 2 Trial of Carfilzomib for Metastatic Castration-resistant Prostate Cancer Following Treatment

NCT02047253

NaSingle-groupOpen-labelTreatment

Summary

This study will test how effective the drug, Carfilzomib, reduces progression of prostate cancer in patients who have previously received chemotherapy and androgen inhibitors. Carfilzomib is approved for multiple myeloma but is not approved for prostate cancer. Therefore, it is considered investigational. Other approved methods of treatment for metastatic prostate cancer have demonstrated only modest benefits. Novel and tolerable agents are necessary to make further gains and extend overall survival.

Timeline

Start
2014-04
Primary completion
2017-06-08
Completion
2017-07-14

Drugs

EvaluationDrugModalityDoseRoute
Subject Carfilzomib Other / unclassified 56 mg/m2 Intravenous
Background Acyclovir Small molecule 400 mg Oral
Background Dexamethasone Small molecule