drugset / Trial / NCT02048384
A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer
Phase 1
Completed
22 enrolled
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Stand Up To Cancer · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a phase 1b, multi-center, open label, randomized study to evaluate the safety and feasibility of administering metformin with or without rapamycin after disease stabilization on chemotherapy in subjects with metastatic PDA.
Timeline
- Start
- 2014-06-10
- Primary completion
- 2018-02
- Completion
- 2019-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metformin | Small molecule | 850 mg | Oral |
| Comparator | Sirolimus | Small molecule | 4 mg | Oral |