drugset / Trial / NCT02051933
The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to determine if botulinum toxin type A (Botox) injections, at the time of surgery for pilon fractures, will improve ankle range-of-motion and functionality.
Timeline
- Start
- 2013-01
- Primary completion
- 2016-03
- Completion
- 2016-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 140 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 170 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 200 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 230 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 260 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 290 iu | Intramuscular |
| Comparator | Botulinum toxin type A | Protein / enzyme biologic | 300 iu | Intramuscular |