drugset / Trial / NCT02056743
Clinical Trials on Evaluate the Red Ginseng and Fermented-Red Ginseng Affect to Drug Metabolizing Enzyme and Transporter in Healthy Volunteers
RandomizedParallel-groupOpen-label
Summary
The purpose of this study is to evaluate the possibility of drug interactions before and after taking red ginseng or fermented-red ginseng by estimating metabolic rate of indicator drugs for cytochrome P450 and P-glycoprotein.
Timeline
- Start
- 2013-09
- Primary completion
- 2013-10
- Completion
- —
Publications
- Kim DS, Kim Y, Jeon JY, Kim MG. Effect of Red Ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers. J Ginseng Res. 2016 Oct;40(4):375-381. doi: 10.1016/j.jgr.2015.11.005. Epub 2015 Dec 17.
- Kim MG, Kim Y, Jeon JY, Kim DS. Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach. Br J Clin Pharmacol. 2016 Dec;82(6):1580-1590. doi: 10.1111/bcp.13080. Epub 2016 Oct 9.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Caffeine | Small molecule | 200 mg | — |
| Subject | Dextromethorphan | Unknown | 30 mg | — |
| Subject | Fexofenadine | Unknown | 30 mg | — |
| Subject | Losartan | Other / unclassified | 50 mg | — |
| Subject | Midazolam | Small molecule | 7.5 mg | — |
| Subject | Omeprazole | Other / unclassified | 20 mg | — |
Indications
No indication recorded.