Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo

NCT02062710 ↗

Phase 4 Completed 22 enrolled Montefiore Medical Center

RandomizedCrossoverDouble-blindTreatment

Summary

The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa flavoring, and, dextromethorphan syrup, compared with placebo.

Timeline

Start: 2014-01
Primary completion: 2014-06
Completion: 2014-06

Publications

Dicpinigaitis PV, Dhar S, Johnson A, Gayle Y, Brew J, Caparros-Wanderley W. Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection. Int J Clin Pharm. 2015 Jun;37(3):471-4. doi: 10.1007/s11096-015-0081-8. Epub 2015 Feb 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dextromethorphan	Unknown	30 mg	Oral
Subject	Diphenhydramine	Unknown	25 mg	Oral
Background	Phenylephrine	Small molecule	10 mg	Oral

Indications

No indication recorded.