drugset / Trial / NCT02082210

A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer

NCT02082210

Phase 1/2 Completed 97 enrolled Eli Lilly and Company
Non-randomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to find a recommended schedule and dose range for Emibetuzumab when given with ramucirumab that may be safely given to participants with cancer. In Part A of this study, escalating doses of Emibetuzumab will be given in combination with a fixed dose of ramucirumab to evaluate the safety of the combination. After a recommended schedule and dose range of Emibetuzumab and ramucirumab has been established, Part B of the study will confirm safety and to see how well certain tumors respond to the combination of study drugs. The average amount of time on study is expected to be about 6 months.

Timeline

Start
2014-03-07
Primary completion
2017-12-05
Completion
2018-01-24

Drugs

EvaluationDrugModalityDoseRoute
Subject Emibetuzumab Monoclonal antibody 750 mg Intravenous
Subject Emibetuzumab Monoclonal antibody 2000 mg Intravenous
Subject Ramucirumab Monoclonal antibody 8 mg/kg Intravenous