Preoperative Dexmedetomidine & EC50 of Propofol

NCT02097407 ↗

Phase 4 Completed 37 enrolled Seoul National University Hospital

RandomizedSingle-groupTriple-blindSupportive care

Summary

Dexmedetomidine is a useful anaesthetic adjuvant for general anaesthesia. In this prospective randomised study, we determined whether preoperative dexmedetomidine administration could reduce the half maximal effective concentration (EC50) of propofol for successful i-gelTM insertion without muscle relaxants.

Timeline

Start: 2012-05
Primary completion: 2012-08
Completion: 2012-08

Outcome

Met primary endpoint

paper The EC50 of propofol for successful i-gel insertion was 3.18 μg/mL in the dexmedetomidine group and 6.75 μg/mL in the control group (p < 0.001). PMID 25394762 ↗

Publications

Jang YE, Kim YC, Yoon HK, Jeon YT, Hwang JW, Kim E, Park HP. A randomized controlled trial of the effect of preoperative dexmedetomidine on the half maximal effective concentration of propofol for successful i-gel insertion without muscle relaxants. J Anesth. 2015 Jun;29(3):338-345. doi: 10.1007/s00540-014-1949-9. Epub 2014 Nov 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	1 ug/kg	Intravenous
Comparator	Propofol	Small molecule	3 ug/ml	—
Comparator	Propofol	Small molecule	5 ug/ml	—

Indications

No indication recorded.