Effects of Antioxidant Dentifrice on Gingivitis

Phase 3 Completed 300 enrolled Lion Corporation Nihon University · collab Osaka University · collab Tohoku University · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.

Timeline

Start: 2006-09
Primary completion: 2007-07
Completion: 2007-07

Publications

Shimabukuro Y, Nakayama Y, Ogata Y, Tamazawa K, Shimauchi H, Nishida T, Ito K, Chikazawa T, Kataoka S, Murakami S. Effects of an ascorbic acid-derivative dentifrice in patients with gingivitis: a double-masked, randomized, controlled clinical trial. J Periodontol. 2015 Jan;86(1):27-35. doi: 10.1902/jop.2014.140138.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	L-ascorbic acid 2-phosphate magnesium salt	Unknown	0.3 %	—
Comparator	Fluoride	Other / unclassified	950 ppm	—

Effects of Antioxidant Dentifrice on Gingivitis

Summary

Timeline

Publications

Drugs

Indications