Drugs / Fluoride
Fluoride
Trials 16
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT03930927 | May 2019 → Oct 2020 | smooth surface dental caries | Raneen Ahmed | Unknown | No outcome recorded |
| Phase 0 | NCT02536352 | Oct 2015 → Oct 2019 | bacterial infectious disease, preterm premature rupture of the membranes | Johns Hopkins University | Completed | No outcome recorded |
| Phase 12 trials · 1 met primary | ||||||
| Phase 1 | NCT00642252 | Jan 2012 → Dec 2013 | dental caries | Indiana Nanotech, LLC | Completed | No outcome recorded |
| Phase 1 | NCT00875212 | Jan 2006 → Dec 2007 | dental caries | Federal University of Paraíba | Completed | Met primary |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT02647203 | Jul 2014 → Nov 2016 | root caries | University of Talca | Completed | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT02913885 | Jan → Jul 2017 | — | Cairo University | Unknown | No outcome recorded |
| Phase 2 | NCT02708160 | Mar → Jun 2016 | dental caries | Colgate Palmolive | Withdrawn | No outcome recorded Stop: Business |
| Phase 2 | NCT03334461 | Dec 2015 → Mar 2022 | enamel caries, gingivitis | University of Rijeka | Completed | No outcome recorded |
| Phase 2 | NCT02388178 | Apr → Jul 2015 | dental caries | Colgate Palmolive | Withdrawn | No outcome recorded Stop: Business |
| Phase 2 | NCT00018447 | Nov 1998 → Oct 2003 | postmenopausal osteoporosis | US Department of Veterans Affairs | Completed | No outcome recorded |
| Phase 32 trials · 1 missed | ||||||
| Phase 3 | NCT05628571 | Feb → Apr 2023 | primary bacterial infectious disease | Hospital Israelita Albert Einstein | Unknown | No outcome recorded |
| Phase 3 | NCT01005966 | Nov 2008 → Mar 2009 | dental caries | GlaxoSmithKline | Completed | Missed primary |
| Phase 43 trials | ||||||
| Phase 4 | NCT06426108 | Jul 2024 → Jan 2025 | — | University of Sao Paulo | Completed | No outcome recorded |
| Phase 4 | NCT07579403 | Jan 2023 → Jun 2024 | dental caries | The Affiliated Hospital of Qingdao University | Completed | No outcome recorded |
| Phase 4 | NCT05810389 | Apr 2017 → Nov 2019 | dental caries | University of Buenos Aires | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT06821724 | Dec 2024 → Jan 2025 | smooth surface dental caries | National Research Centre, Egypt | Completed | No outcome recorded |
| Comparator or background therapy34 trials | ||||||
| Phase 1 | NCT04368533 Comparator | Feb 2019 → Aug 2020 | dental caries | University of California, San Francisco | Completed | No outcome recorded |
| Phase 1 | NCT03724578 Comparator | Jan 2019 → Feb 2020 | dental caries | Cairo University | Unknown | No outcome recorded |
| Phase 1 | NCT01079910 Background | Dec 2009 | gingivitis | GlaxoSmithKline | Withdrawn | No outcome recorded |
| Phase 2 | NCT07177053 Comparator | Nov 2025 → Nov 2026 expected | — | Dubai Health | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT01014143 Comparator | Aug → Sep 2007 | smooth surface dental caries | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT02193165 Comparator | Jul → Aug 2014 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00763269 Comparator | Sep → Dec 2008 | dentin sensitivity | Colgate Palmolive | Completed | Missed primary |
| Phase 3 | NCT00758290 Background | May → Jul 2008 | gingival disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00762853 Comparator | May → Jun 2008 | smooth surface dental caries | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00762177 Comparator | May → Sep 2008 | — | Colgate Palmolive | Completed | Missed primary |
| Phase 3 | NCT00762450 Comparator | Apr → Aug 2008 | smooth surface dental caries | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00763048 Comparator | Mar → Apr 2008 | gingival disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00758563 Comparator | Mar → Apr 2008 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT01024738 Comparator | Mar → Apr 2008 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00761930 Comparator | Mar → Jun 2008 | gingival disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00762515 Comparator | Feb → Aug 2008 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00926029 Comparator | Jan → Apr 2008 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00765167 Comparator | Nov → Dec 2007 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00981825 Comparator | Oct → Dec 2007 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00966953 Background | Oct 2007 → Jan 2008 | gingival disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00758394 Comparator | Sep → Nov 2007 | — | Colgate Palmolive | Completed | Met primary |
| Phase 3 | NCT01072201 Comparator | Jun → Dec 2007 | mucositis | Colgate Palmolive | Completed | Missed primary |
| Phase 3 | NCT00926328 Comparator | Jun → Dec 2007 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00762619 Comparator | Apr 2007 → Aug 2008 | gingival disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT02102295 Comparator | Sep 2006 → Jul 2007 | gingivitis | Lion Corporation | Completed | No outcome recorded |
| Phase 3 | NCT00763256 Comparator | May 2006 → Aug 2009 | periodontal disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00762762 Comparator | Mar 2006 → Dec 2008 | periodontitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT00763165 Comparator | Nov 2000 → Dec 2009 | periodontal disorder | Colgate Palmolive | Unknown | No outcome recorded |
| Phase 4 | NCT02360995 Comparator | Jun → Aug 2014 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| — | NCT06378008 Comparator | Apr → Sep 2024 | dentin sensitivity | HALEON | Completed | Met primary |
| — | NCT06354270 Comparator | Apr → Jun 2024 | dentin sensitivity | HALEON | Completed | Met primary |
| — | NCT03143023 Comparator | Jun → Dec 2017 | dental caries | Cairo University | Unknown | No outcome recorded |
| — | NCT02436473 Comparator | Dec 2015 → Nov 2016 | dental caries | GlaxoSmithKline | Withdrawn | No outcome recorded Stop: Enrollment |
| — | NCT00066040 Background | Jan 2001 → Jan 2006 | dental caries | New York University | Completed | No outcome recorded |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2011-03-01 | GlaxoSmithKline | World’s first everyday fluoride toothpaste with NovaMin® technology that can repair sensitive teeth gsk.com ↗ |
Evidence & citations 5 cited values
Every value below carries the sentence it was read from. 50 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | fluoride | “Participants will brush their teeth with a commercially available, soft-bristle adult toothbrush and toothpaste containing amine-based zinc lactate (0.1%) and fluoride (1400 ppm F).” NCT05628571 ↗49“This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model” NCT01005966 ↗ “Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.” NCT03930927 ↗ “twice per day with high-fluorides gel (Mirafluor K gel cola 6150 ppm F pH 5.1)” NCT03334461 ↗ “Fluoride has been successfully used in preventive programs for root caries.” NCT02647203 ↗ “test toothpaste containing 1150 parts per million (ppm) of fluoride (F)” NCT02436473 ↗ “Fluoride-containing tooth paste [1450ppm fluoride] (control group)” NCT07177053 ↗ “Control toothpaste was containing 950 ppm fluoride.” NCT02102295 ↗ |
| Known as | Duraphat | “Duraphat fluoride varnish” NCT00066040 ↗ |
| Known as | MFPSR | “This study is designed to determine if combining parathyroid (PTH 1-34) with fluoride (MFPSR) therapy in a cyclic treatment regimen will:” NCT00018447 ↗ |
| Modality | Other / unclassified | “fluoridated toothpaste (Colgate Total PROTECTION ACTIVE)” NCT07177053 ↗ |
| Route | Oral | “Fluoride will be administered orally one 76mg tablet twice daily (providing 20 mg fluoride/day), during the last 2 months of each cycle.” NCT00018447 ↗ |