drugset / Trial / NCT02117726
Impact of Various Sedation Regimens on the Incidence of Delirium
RandomizedParallel-groupDouble-blindTreatment
Summary
Sedation drugs that are commonly used in ICU in treatment of ARDS, includes propofol, midazolam and dexmedetomidine . Among these, both dexmedetomidine and propofol have been reported to be used together with midazolam in ICU and the combination of propofol and midazolam is most commonly used, but things follow include a high incidence rate of delirium, But the combination of midazolam and dexmedetomidine may have complementary advantages and could have be a better choice for sedation. In this study, we attempted to observe the effects of two different drug regimens on delirium incidence rates in severe ARDS patients' : midazolam and propofol vs propofol and dexmedetomidine .
Timeline
- Start
- 2014-05
- Primary completion
- 2015-12
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | — |
| Subject | Dexmedetomidine | Other / unclassified | 1.4 ug/kg | — |
| Comparator | Propofol | Small molecule | 0.3 mg/kg | — |
| Comparator | Propofol | Small molecule | 4 mg/kg | — |
| Background | Midazolam | Small molecule | 0.02 mg/kg | Intravenous |
| Background | Midazolam | Small molecule | 0.1 mg/kg | Intravenous |