drugset / Trial / NCT02119338

5-ALA in Recurrent Glioma

NCT02119338

NaSingle-groupOpen-labelDiagnostic

Summary

The investigators propose a single-center, non-randomized, single-arm study at the Barrow Neurological Institute/St. Joseph's Hospital for recurrent glioma. The 5-ALA for recurrent glioma study will correlate presence of fluorescence in tumor tissue with pathological findings. This will be done using three cohorts in dose escalation. The investigators' hypothesis is that (for both low- and high-grade gliomas,) a lower dose of 5-ALA will result in less false positive fluorescence.

Timeline

Start
2014-02
Primary completion
2017-06
Completion
2017-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Aminolevulinic Acid Diagnostic / imaging agent 5 mg/kg Oral
Subject Aminolevulinic Acid Diagnostic / imaging agent 10 mg/kg Oral
Subject Aminolevulinic Acid Diagnostic / imaging agent 20 mg/kg Oral

Indications