The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia

Completed 16 enrolled Academic Medical Center - University of Amsterdam

RandomizedParallel-groupOpen-labelBasic science

Summary

The purpose of this study is to determine whether treatment with antibiotics, which harm the gut flora, causes the immune system to be less effective.

Timeline

Start: 2014-06
Primary completion: 2015-12
Completion: 2015-12

Publications

Haak BW, Lankelma JM, Hugenholtz F, Belzer C, de Vos WM, Wiersinga WJ. Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans. J Antimicrob Chemother. 2019 Mar 1;74(3):782-786. doi: 10.1093/jac/dky471.
Lankelma JM, Cranendonk DR, Belzer C, de Vos AF, de Vos WM, van der Poll T, Wiersinga WJ. Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study. Gut. 2017 Sep;66(9):1623-1630. doi: 10.1136/gutjnl-2016-312132. Epub 2016 Jun 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ciprofloxacin	Small molecule	500 mg	Oral
Subject	Metronidazole	Small molecule	500 mg	Oral
Subject	Vancomycin	Other / unclassified	500 mg	Oral

Indications

No indication recorded.