Comparator Study of the Effect of Glycopyrrolate and Glycopyrronium in Subjects With Axillary Hyperhidrosis

Phase 2 Completed 105 enrolled Journey Medical Corporation

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of the study is to assess the safety of 2 doses of glycopyrrolate compared to 2 doses of glycopyrronium and vehicle (5 treatment arms) for the treatment of axillary hyperhidrosis when applied once daily for 4 weeks followed by a 2-week post-dose period.

Timeline

Start: 2014-04
Primary completion: 2015-01
Completion: 2015-01

Publications

Pariser DM, Lain EL, Mamelok RD, Drew J, Mould DR. Limited Systemic Exposure with Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis. Clin Pharmacokinet. 2021 May;60(5):665-676. doi: 10.1007/s40262-020-00975-y. Epub 2021 Jan 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Glycopyrrolate	Small molecule	2 %	Topical
Subject	Glycopyrrolate	Small molecule	3 %	Topical
Comparator	Glycopyrronium	Unknown	2.5 %	Topical
Comparator	Glycopyrronium	Unknown	3.75 %	Topical

Indications

No indication recorded.