The Treatment of Osteoporosis Using a Combination of Teriparatide (Forteo) and Denosumab

Phase 4 Unknown 60 enrolled Health Research, Inc.

RandomizedParallel-groupOpen-labelTreatment

Summary

This is a three-year study to evaluate the effect of sequential therapy of Forteo (teriparatide) and denosumab on bone density at the spine, hip, leg and forearm.

Timeline

Start: 2013-08
Primary completion: 2018-08
Completion: 2018-08

Publications

Cosman F, McMahon D, Dempster D, Nieves JW. Standard Versus Cyclic Teriparatide and Denosumab Treatment for Osteoporosis: A Randomized Trial. J Bone Miner Res. 2020 Feb;35(2):219-225. doi: 10.1002/jbmr.3850. Epub 2019 Oct 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Denosumab	Monoclonal antibody	—	Subcutaneous
Subject	Teriparatide	Protein / enzyme biologic	—	Subcutaneous

The Treatment of Osteoporosis Using a Combination of Teriparatide (Forteo) and Denosumab

Summary

Timeline

Publications

Drugs

Indications