drugset / Trial / NCT02135263
Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype
Phase 4
Completed
44 enrolled
Bispebjerg Hospital
Duke University · collabMental Health Centre Sct. Hans (Denmark) · collabThe Leiden Academic Center for Drug Research (LACDR) · collabThe Ministry of Science, Technology and Innovation, Denmark · collabUniversity of Copenhagen · collab
Non-randomizedCrossoverOpen-labelBasic science
Summary
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of two CES1 dependent drugs, enalapril and methylphenidate.
Timeline
- Start
- 2012-04
- Primary completion
- 2014-05
- Completion
- 2014-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Enalapril | Other / unclassified | 10 mg | — |
| Subject | Methylphenidate | Small molecule | 10 mg | — |