drugset / Trial / NCT02142309

Glycemic Durability After Metformin Failure

NCT02142309

Phase 4 Unknown 450 enrolled University of Campania Luigi Vanvitelli
RandomizedParallel-groupDouble-blindTreatment

Summary

Type 2 diabetes is epidemic and its treatment has become more and more difficult. Consensus algorithms have been developed to help clinicians to select among the numerous medications and their combinations for achieving and maintaining a target glycated hemoglobin A1c (HbA1c) of \<7%. AMAZING, a pragmatic clinical trial, aims to compare commonly used oral diabetes medications, when combined with metformin, on glycemia-lowering effectiveness.

Timeline

Start
2005-10
Primary completion
2015-10
Completion
2017-01

Drugs

EvaluationDrugModalityDoseRoute
Subject CANAGLIFLOZIN ANHYDROUS Small molecule 300 mg
Subject Glimepiride Small molecule 4 mg
Subject Pioglitazone Small molecule 30 mg
Subject Vildagliptin Other / unclassified 50 mg