drugset
drugset / Trial / NCT02165176

Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis

NCT02165176 ↗

Phase 1 Completed 24 enrolled Johns Hopkins University RTI International · collabSubstance Abuse and Mental Health Services Administration (SAMHSA) · collab
RandomizedSingle-groupDouble-blindBasic science

Summary

Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of oral cannabis dose effects on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. In the present study we evaluated the detection of cannabinoids in oral fluid, plasma, hair, and urine for up to 9 days following consumption of oral cannabis (10mg, 25mg, or 50mg THC). The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of oral cannabis administration and can inform policies regarding clinical, workplace and roadside drug testing programs.

Timeline

Start
2014-06
Primary completion
2014-09
Completion
2014-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Cannabis Traditional medicine (herbal / TCM) 10 mg Oral
Subject Cannabis Traditional medicine (herbal / TCM) 25 mg Oral
Subject Cannabis Traditional medicine (herbal / TCM) 50 mg Oral

Indications

No indication recorded.