Inflammation After One Lung Ventilation
Summary
The aim of the study was to prospectively investigate the influence of one-lung ventilation (OLV) on the inflammatory response and to identify possible antiinflammatory effects of the volatile anaesthetic sevoflurane. Forty patients undergoing thoracic surgery with OLV were enrolled in this prospective, randomised study. The patients were randomly allocated into two groups to receive either propofol (Group P) or sevoflurane (Group S) for induction and maintenance of anaesthesia. Inflammatory mediators (Interleukin 6 (IL6), Interleukin8 (IL8), Interleukin 10 (IL10), (C- reactive protein)CRP) were measured intra- and postoperatively. Six hours after surgery oxygenation index (PaO2/FiO2) was calculated and chest X ray was taken and assessed. The clinical outcome determinated by postoperative adverse events was assessed as the secondary endpoint.
Timeline
- Start
- 2008-07
- Primary completion
- 2013-09
- Completion
- 2014-01
Publications
- Results De Conno E, Steurer MP, Wittlinger M, Zalunardo MP, Weder W, Schneiter D, Schimmer RC, Klaghofer R, Neff TA, Schmid ER, Spahn DR, Z'graggen BR, Urner M, Beck-Schimmer B. Anesthetic-induced improvement of the inflammatory response to one-lung ventilation. Anesthesiology. 2009 Jun;110(6):1316-26. doi: 10.1097/ALN.0b013e3181a10731.
- Results Schilling T, Kozian A, Senturk M, Huth C, Reinhold A, Hedenstierna G, Hachenberg T. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology. 2011 Jul;115(1):65-74. doi: 10.1097/ALN.0b013e318214b9de.
- Results Schilling T, Kozian A, Kretzschmar M, Huth C, Welte T, Buhling F, Hedenstierna G, Hachenberg T. Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation. Br J Anaesth. 2007 Sep;99(3):368-75. doi: 10.1093/bja/aem184. Epub 2007 Jul 9.
- Potocnik I, Novak Jankovic V, Sostaric M, Jerin A, Stupnik T, Skitek M, Markovic-Bozic J, Klokocovnik T. Antiinflammatory effect of sevoflurane in open lung surgery with one-lung ventilation. Croat Med J. 2014 Dec;55(6):628-37. doi: 10.3325/cmj.2014.55.628.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 4 mg/kg | — |
| Comparator | Propofol | Small molecule | 6 mg/kg | — |
| Subject | Sevoflurane | Other / unclassified | 3 % | — |
| Subject | Sevoflurane | Other / unclassified | 5 % | — |
Indications
No indication recorded.