drugset / Trial / NCT02189668
Non-operative Management of Pediatric Appendicitis With an Appendicoltih
Non-randomizedParallel-groupOpen-labelTreatment
Summary
To determine if non-operative management with antibiotics alone is a feasible treatment alternative for pediatric patients with uncomplicated acute appendicitis with an appendicolith identified on imaging.
Timeline
- Start
- 2014-07
- Primary completion
- 2015-07
- Completion
- 2015-07
Outcome
Missed primary endpoint
Stopped: “High failure rate”
paper Nonoperative management of acute appendicitis with an appendicolith in children resulted in an unacceptably high failure rate. PMID 27018085 ↗
Publications
- Background Minneci PC, Sulkowski JP, Nacion KM, Mahida JB, Cooper JN, Moss RL, Deans KJ. Feasibility of a nonoperative management strategy for uncomplicated acute appendicitis in children. J Am Coll Surg. 2014 Aug;219(2):272-9. doi: 10.1016/j.jamcollsurg.2014.02.031. Epub 2014 Apr 13.
- Results Mahida JB, Lodwick DL, Nacion KM, Sulkowski JP, Leonhart KL, Cooper JN, Ambeba EJ, Deans KJ, Minneci PC. High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg. 2016 Jun;51(6):908-11. doi: 10.1016/j.jpedsurg.2016.02.056. Epub 2016 Mar 2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Augmentin | Unknown | — | — |
| Subject | Ciprofloxacin | Small molecule | — | — |
| Subject | Metronidazole | Small molecule | — | — |
| Subject | Piperacillin/Tazobactam | Unknown | — | — |