To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery

NCT02204813 ↗

Phase 1 Completed 13 enrolled Washington University School of Medicine National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

CrossoverSingle-blindBasic science

Summary

There is a marked and long-lasting improvement in glucose homeostasis that follows Roux-en-y gastric bypass surgery (RYGB) in humans. This improvement has been attributed in large part to an intestinal hormone, called GLP-1, that is released into the circulation immediately after eating. The purpose of this study is to determine if GLP-1 mediates the beneficial effects of RYGB surgery on glucose homeostasis in humans.

Timeline

Start: 2014-07
Primary completion: 2015-11-17
Completion: 2015-11-17

Publications

Results Sterl K, Wang S, Oestricker L, Wallendorf MJ, Patterson BW, Reeds DN, Wice BM. Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery. Peptides. 2016 Aug;82:76-84. doi: 10.1016/j.peptides.2016.06.001. Epub 2016 Jun 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Xenin-25	Peptide	4 unknown	Intravenous
Subject	Xenin-25	Peptide	12 unknown	Intravenous
Subject	Xenin-25	Peptide	24 unknown	Intravenous

Indications

No indication recorded.