drugset / Trial / NCT02205775
Rosuvastatin for Reduction of Myocardial Damage and Systemic Inflammation During Coronary Angioplasty
Phase 3
Terminated
280 enrolled
G. d'Annunzio University
Working Group Aterosclerosi, Trombosi e Biologia Vascolare · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Myocardial necrosis is relatively frequent after percutaneous coronary intervention and is associated with higher mortality during the follow-up. Since anti-inflammatory properties of statins have been demonstrated and the benefit of statins in acute coronary syndromes have been proven, this study aims at testing the hypothesis that the pre-procedural intensive statin treatment reduce the extent of peri-procedural necrosis.
Timeline
- Start
- 2010-05
- Primary completion
- 2012-03
- Completion
- 2012-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 40 mg | — |
| Subject | Ezetimibe | Unknown | 10 mg | — |
| Subject | Rosuvastatin | Small molecule | 5 mg | — |
| Subject | Rosuvastatin | Small molecule | 40 mg | — |