drugset / Trial / NCT02218203
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
Phase 2
Completed
26 enrolled
Brigham and Women's Hospital
National Institute of Neurological Disorders and Stroke (NINDS) · collab
RandomizedFactorialQuadruple-blindTreatment
Summary
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and intravenous (IV) lidocaine in central neuropathic pain following spinal cord injury.
Timeline
- Start
- 2003-04
- Primary completion
- 2008-01
- Completion
- 2008-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dextromethorphan | Unknown | — | Oral |
| Subject | Lidocaine | Other / unclassified | 0 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 1 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 2 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 4 mg/kg | Intravenous |