drugset / Trial / NCT02223520
Treating Parents to Reduce NICU Transmission of Staphylococcus Aureus Trial
Completed
307 enrolled
Johns Hopkins University
Agency for Healthcare Research and Quality (AHRQ) · collab
RandomizedParallel-groupTriple-blindPrevention
Summary
This trial will test the hypothesis that treating parents of neonates requiring NICU care with intranasal mupirocin and topical chlorhexidine bathing will reduce the spread of S. aureus from parents to neonates.
Timeline
- Start
- 2014-11
- Primary completion
- 2019-10-31
- Completion
- 2019-10-31
Publications
- Milstone AM, Voskertchian A, Koontz DW, Khamash DF, Ross T, Aucott SW, Gilmore MM, Cosgrove SE, Carroll KC, Colantuoni E. Effect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial. JAMA. 2020 Jan 28;323(4):319-328. doi: 10.1001/jama.2019.20785.
- Milstone AM, Koontz DW, Voskertchian A, Popoola VO, Harrelson K, Ross T, Aucott SW, Gilmore MM, Carroll KC, Colantuoni E. Treating Parents to Reduce NICU Transmission of Staphylococcus aureus (TREAT PARENTS) trial: protocol of a multisite randomised, double-blind, placebo-controlled trial. BMJ Open. 2015 Sep 9;5(9):e009274. doi: 10.1136/bmjopen-2015-009274.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Chlorhexidine | Small molecule | 2 % | Topical |
| Comparator | Mupirocin | Small molecule | 2 % | Intranasal |