drugset / Trial / NCT02231931
Drug-drug Interaction Between Digoxin, Furosemide, Metformin, and Rosuvastatin
RandomizedCrossoverOpen-labelTreatment
Summary
To investigate the mutual interaction potential of digoxin, furosemide, metformin, and rosuvastatin when given alone or together as a cocktail, and to investigate the effect of high doses of metformin or furosemide on pharmacokinetics of the other cocktail compounds
Timeline
- Start
- 2014-09-01
- Primary completion
- 2015-01-01
- Completion
- 2015-01-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | — | Oral |
| Subject | Furosemide | Other / unclassified | 0.5 ml | Oral |
| Subject | Furosemide | Other / unclassified | 2 ml | Oral |
| Subject | Metformin | Small molecule | — | Oral |
| Subject | Rosuvastatin | Small molecule | — | Oral |
Indications
No indication recorded.