Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities

Phase 1 Completed 21 enrolled University of Rochester

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The objectives of this Phase 1 study are to evaluate the safety and feasibility of methylene-blue-mediated photodynamic therapy (MB-PDT) performed at the time of abscess drainage to treat deep tissue abscesses. Safety will be evaluated by physical examination and imaging and laboratory studies in order to identify adverse events that may be induced by MB-PDT. We hypothesize that MB-PDT will be a safe and feasible intervention for this patient population. Optical measurements will additionally be performed at the abscess wall to determine optical properties and methylene blue uptake.

Timeline

Start: 2014-09
Primary completion: 2023-09
Completion: 2023-09

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methylene Blue	Diagnostic / imaging agent	1 mg/ml	Other
Background	Intralipid	Other / unclassified	1 %	Other

Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities

Summary

Timeline

Publications

Drugs

Indications