Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate

Summary

This is a phase I clinical trial in healthy volunteers comparing the effect of lysine acetylsalicylate or aspirin on platelet function.

Timeline

Start

2013-05

Primary completion

2014-06

Completion

2014-06

Outcome

Met primary endpoint

paper was significantly higher in subjects treated with LA compared with aspirin: 85.3% versus 44.3%, respectively, P=0.003. PMID 25957056 ↗

Publications

• Vivas D, Martin A, Bernardo E, Ortega-Pozzi MA, Tirado G, Fernandez C, Vilacosta I, Nunez-Gil I, Macaya C, Fernandez-Ortiz A. Impact of Intravenous Lysine Acetylsalicylate Versus Oral Aspirin on Prasugrel-Inhibited Platelets: Results of a Prospective, Randomized, Crossover Study (the ECCLIPSE Trial). Circ Cardiovasc Interv. 2015 May;8(5):e002281. doi: 10.1161/CIRCINTERVENTIONS.114.002281.

Drugs

Indications

No indication recorded.