drugset / Trial / NCT02243254
Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
RandomizedParallel-groupTriple-blindSupportive care
Summary
Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
Timeline
- Start
- 2014-07
- Primary completion
- 2015-04
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ibuprofen | Small molecule | 800 mg | Intravenous |
| Comparator | Remifentanil | Small molecule | 1 ng/ml | — |
| Comparator | Remifentanil | Small molecule | 4 ng/ml | — |
Indications
No indication recorded.