Mifepristone for the Prevention of Relapses of Alcohol Drinking

Summary

The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone

Timeline

Start

2014-09

Primary completion

2021-12-21

Completion

2021-12-21

Publications

• Results Simms JA, Haass-Koffler CL, Bito-Onon J, Li R, Bartlett SE. Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology. 2012 Mar;37(4):906-18. doi: 10.1038/npp.2011.268. Epub 2011 Nov 2.
• Results Haass-Koffler CL, Magill M, Cannella N, Brown JC, Aoun EG, Cioe PA, Sinha R, Swift RM, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress-induced alcohol craving: A human laboratory study. Addict Biol. 2023 Jul;28(7):e13288. doi: 10.1111/adb.13288.
• Haass-Koffler CL, Magill M, Cannella N, Brown JC, Aoun EG, Cioe PA, Sinha R, Swift RM, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress-Induced alcohol craving: a translational crossover randomized trial. medRxiv [Preprint]. 2023 Jan 4:2023.01.02.23284122. doi: 10.1101/2023.01.02.23284122.

Drugs

Indications