Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

Phase 1 Completed 32 enrolled Novo Nordisk A/S

Non-randomizedCrossoverOpen-labelTreatment

Summary

This trial is conducted in Europe. The aim of this trial is to investigate the influence of oral semaglutide on pharmacokinetics (the exposure of the trial drug in the body) of metformin and digoxin in healthy subjects.

Timeline

Start: 2014-09-18
Primary completion: 2015-03-06
Completion: 2015-03-06

Publications

Background Baekdal TA, Borregaard J, Hansen CW, Thomsen M, Anderson TW. Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects. Clin Pharmacokinet. 2019 Sep;58(9):1193-1203. doi: 10.1007/s40262-019-00756-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Digoxin	Other / unclassified	0.5 mg	Oral
Subject	Metformin	Small molecule	850 mg	Oral
Subject	Semaglutide	Peptide	20 mg	Oral

Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

Summary

Timeline

Publications

Drugs

Indications