Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?

Completed 21 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverTriple-blindDiagnostic

Summary

The purpose of this study is to examine whether two clinically sensible dose regimen of fentanyl (low dose vs. high dose) lead to different pain scores as measured by the nonverbal rating scale (NRS) in healthy volunteers at 4.5 to 6.5 hours after fentanyl application. Pain modalities tested will include transdermal electrical stimulation and cold pressor pain. The investigators hypothesize that the high dose fentanyl group will have an increase of approximately 20% in the NRS.

Timeline

Start: 2014-08
Primary completion: 2015-01
Completion: 2015-01

Publications

Mauermann E, Blum CA, Lurati Buse G, Bandschapp O, Ruppen W. Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial. Eur J Anaesthesiol. 2017 May;34(5):306-314. doi: 10.1097/EJA.0000000000000592.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	1 ug/kg	—
Subject	Fentanyl	Other / unclassified	10 ug/kg	—

Indications

No indication recorded.