Platelet -Rich Plasma (PRP) Injection for the Treatment of Severe Dry Eye

Phase 3 Completed 30 enrolled National University of Colombia

RandomizedParallel-groupOpen-labelTreatment

Summary

Dry eye is a chronic condition that decreases function and affect visual function with severe discapacity until now treatments are based in artificial eye drops. Platelet rich plasma has emerged as a strategy for cellular restoration, the purpose of this study is to evaluate their effects in lacrimal production and safety of this intervention in patients with severe dry eye.

Timeline

Start: 2014-11-30
Primary completion: 2015-09-30
Completion: 2016-04-20

Outcome

Met primary endpoint

paper The intervention group showed improvements in all primary outcome measures when compared with the control group, including a reduction in corneal staining (p<0.001), PMID 29970389 ↗

Publications

Avila MY, Igua AM, Mora AM. Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye. Br J Ophthalmol. 2018 Jul 3:bjophthalmol-2018-312072. doi: 10.1136/bjophthalmol-2018-312072. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Platelet Rich Plasma	Other / unclassified	—	—
Comparator	Hyaluronic Acid	Other / unclassified	—	Topical