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Drugs / Hyaluronic Acid
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Hyaluronic Acid

also known as Durolane · hyaluronan · Synvisc-One · Gengigel · HA · HYADENT BG · Hyal One · HYLO COMOD eye drops · +48 more

Other / unclassified targets CD44, PGRMC1 via activation

Developed for
osteoarthritis, knee · periodontitis · chronic periodontitis · gingival recession · dry eye syndrome · frozen shoulder · osteoarthritis · temporomandibular joint disorder
+68 more · arthropathy · impacted teeth, multiple · interstitial cystitis · temporomandibular joint dysfunction syndrome · acne · adhesions of uterus · aphthous stomatitis · bursitis · carpal tunnel syndrome · chronic pain syndrome · cystitis · gingival disorder · infertility disorder · mouth disorder · periodontal disorder · premature ejaculation · sudden hearing loss disorder · alpha 1-antitrypsin deficiency · anosmia · articular cartilage disorder · chemotherapy-induced oral mucositis · corneal edema · dacryocystitis · drug-induced hearing loss · epicondylitis · gingivitis · hyperpigmentation of the skin · intervertebral disk degenerative disorder · larynx cancer · lumbar spinal stenosis · Meniere disease · noise induced hearing loss · osteoarthritis, hip · papilloma · paratenonitis with tendinosis · Peyronie disease · postmenopausal atrophic vaginitis · presbyopia · pulmonary emphysema · rotator cuff syndrome · sensorineural hearing loss disorder · sexual disorder · shoulder impingement syndrome · skin atrophy · skin disorder · sudden sensorineural hearing loss · tendinitis · tendinosis · tooth resorption · trigger thumb · urinary tract infection · vernal conjunctivitis · alveolar periostitis · Asherman syndrome · chronic gingivitis · diabetes mellitus · eye adnexa disorder · hearing loss disorder · hemophilic arthropathy · hemorrhoid · lichen planus, oral · oral submucous fibrosis · patellar tendinitis · periodontitis, aggressive · radiation proctitis · subacute bursitis · synovitis · vaginal disorder
Investigated by
Cairo University · Anika Therapeutics, Inc. · Damascus University · Rizzoli Orthopaedic Institute · Samsung Medical Center · Shin Kong Wu Ho-Su Memorial Hospital
+153 more · Taipei Veterans General Hospital, Taiwan · Tanta University · Yuzuncu Yil University · Ain Shams University · Batman University · Benha University · Kafrelsheikh University · Mahidol University · Mansoura University · Queen Mary University of London · Sana'a University · Seoul National University Hospital · Tri-Service General Hospital (TSGH) · University of Milan · University of Pennsylvania · University of Roma La Sapienza · University of Sao Paulo General Hospital · Affinity Health Research Institute · Al-Azhar University · Al-Nahrain University · All India Institute of Medical Sciences, Bhubaneswar · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Assiut University · Atlas University · Aya Elleithy · Ayhman Al Afif · BLAD-HYA Group · BMG Pharma · Badr University · Bangladesh Medical University · Barzilai Medical Center · Basel khaled mohamed · Beirut Arab University · Carol Davila University of Medicine and Pharmacy · Centre Hospitalier Departemental Vendee · Centro di Ricerca Clinica Salentino · Chang Gung Memorial Hospital · Clinical Center of Vojvodina · Colgate Palmolive · Concordia Dent Srl · Dubai Health Authority · EPC Education s.r.o. · Ehab Haider Hassan El-emam · Emory University · Erin Newton · Eulji University · Federal University of Minas Gerais · Fortius Clinic · Future University in Egypt · Gansu Provincial Maternal and Child Health Care Hospital · Gazi University · Geistlich Pharma AG · Genesis Orthopedics and Sports Medicine · Gerard Turino · Hacettepe University · Hadassah Medical Organization · Hallym University Kangnam Sacred Heart Hospital · He Eye Hospital · Hospital Clinic of Barcelona · Hospital Regional Tlalnepantla · Hospital Universitario 12 de Octubre · Hospital Universitario Virgen de la Arrixaca · Huazhong University of Science and Technology · Huons Co., Ltd. · Ibrahim Samy Kalboush · Indiana University · Indonesia University · Instituto de Oftalmología Fundación Conde de Valenciana · JDS Therapeutics, LLC · Jagiellonian University · Jiangxi Maternal and Child Health Hospital · Johns Hopkins University · Jordan University of Science and Technology · all 159 on the full record

Trials 156 · started per year

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07821866 Apr 2026 → Apr 2027 expected — Future University in Egypt Active not recruiting No outcome recorded
Phase 0 NCT07825155 Mar → Jun 2026 overdue carpal tunnel syndrome Tanta University Recruiting No outcome recorded
Phase 0 NCT04645303 Nov 2020 → Apr 2021 arthropathy Dubai Health Authority Unknown No outcome recorded
Phase 18 trials · 1 missed
Phase 1 NCT07662226 Aug → Nov 2026 expected gingival disorder Cairo University Not yet recruiting No outcome recorded
Phase 1 NCT07658118 Jul → Dec 2026 expected chronic pain syndrome, interstitial cystitis Sverdlovsk Regional Clinical Hospital No.1 Not yet recruiting No outcome recorded
Phase 1 NCT05851560 May → Sep 2023 goiter, thyroid cancer National Taiwan University Hospital Completed Missed primary
Phase 1 NCT06997731 May 2023 → Jan 2025 chronic periodontitis Kafrelsheikh University Completed No outcome recorded
Phase 1 NCT05765240 Feb → Aug 2023 — Atlas University Unknown No outcome recorded
Phase 1 NCT05006911 Aug → Sep 2021 presbyopia Optall Vision Unknown No outcome recorded
Phase 1 NCT03754010 Aug 2017 → Apr 2018 periodontitis Yuzuncu Yil University Completed No outcome recorded
Phase 1 NCT03047096 Feb → Aug 2017 osteoarthritis Zhongda Hospital Unknown No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT06437054 Dec 2026 sensorineural hearing loss disorder, sudden hearing loss disorder Seoul National University Hospital Withdrawn No outcome recorded Stop: Enrollment
Phase 1/2 NCT07581613 Nov 2026 → Jun 2029 expected chronic periodontitis Siddharth Shanbhag Not yet recruiting No outcome recorded
Phase 1/2 NCT06694532 Oct 2023 → Feb 2026 overdue temporomandibular joint disorder Basel khaled mohamed Recruiting No outcome recorded
Phase 1/2 NCT04766853 Jul 2021 → Apr 2023 Meniere disease, drug-induced hearing loss, noise induced hearing loss, sudden hearing loss disorder Seoul National University Hospital Completed No outcome recorded
Phase 1/2 NCT03728244 Feb → Nov 2019 gingival recession Cairo University Unknown No outcome recorded
Phase 1/2 NCT02709525 Jul 2012 → Jul 2015 periodontal disorder Federal University of Minas Gerais Completed No outcome recorded
Phase 1/2 NCT01442571 — articular cartilage disorder Hadassah Medical Organization Unknown No outcome recorded
Phase 29 trials
Phase 2 NCT06098456 Nov 2023 → May 2024 papilloma Centro di Ricerca Clinica Salentino Completed No outcome recorded
Phase 2 NCT06937645 Sep 2023 → May 2025 overdue infertility disorder Al-Nahrain University Recruiting No outcome recorded
Phase 2 NCT06170346 Nov 2022 → Jul 2023 — Padjadjaran University Completed No outcome recorded
Phase 2 NCT03656484 Jan → Dec 2019 chronic periodontitis Concordia Dent Srl Completed No outcome recorded
Phase 2 NCT03384095 Dec 2018 arthropathy, breast cancer Erin Newton Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT02832713 Jun 2017 → Oct 2021 osteoarthritis, knee University Hospital, Strasbourg, France Unknown No outcome recorded
Phase 2 NCT03114020 Mar 2017 → Nov 2019 alpha 1-antitrypsin deficiency, pulmonary emphysema Gerard Turino Completed No outcome recorded
Phase 2 NCT04525066 Aug 2013 → Aug 2018 head and neck squamous cell carcinoma, larynx cancer, voice disorders Ayhman Al Afif Completed No outcome recorded
Phase 2 NCT02207608 Sep 2011 → Aug 2012 — University of Rome Tor Vergata Completed No outcome recorded
Phase 2/33 trials · 1 met primary
Phase 2/3 NCT05450458 Feb 2023 → Oct 2024 — Hospital Regional Tlalnepantla Completed Met primary
Phase 2/3 NCT04821804 Jan → Sep 2020 gingival recession Jordan University of Science and Technology Completed No outcome recorded
Phase 2/3 NCT03131882 Oct 2016 → Jun 2017 trigger thumb Mahidol University Unknown No outcome recorded
Phase 323 trials · 2 met primary · 2 missed
Phase 3 NCT07474714 Feb → Aug 2026 overdue carpal tunnel syndrome Minia University Hospital Not yet recruiting No outcome recorded
Phase 3 NCT07102225 May 2025 → Sep 2026 overdue osteoarthritis, knee Bangladesh Medical University Active not recruiting No outcome recorded
Phase 3 NCT06376981 Sep 2024 → Dec 2026 expected tendinitis Centre Hospitalier Departemental Vendee Recruiting No outcome recorded
Phase 3 NCT07317596 Jun 2024 → Jul 2026 overdue — Sana'a University Enrolling by invitation No outcome recorded
Phase 3 NCT06388070 May 2024 → Mar 2025 dry eye syndrome Huons Co., Ltd. Completed Met primary
Phase 3 NCT06290219 Mar → Sep 2024 anosmia Taichung Veterans General Hospital Unknown No outcome recorded
Phase 3 NCT06238934 Mar 2024 → Mar 2025 overdue osteoarthritis, knee National Institute of Traumatology and Orthopaedics Not yet recruiting No outcome recorded
Phase 3 NCT07183436 Nov 2023 → Jul 2025 frozen shoulder Mahidol University Completed No outcome recorded
Phase 3 NCT05116306 Nov 2021 → Dec 2023 tooth resorption Ain Shams University Unknown No outcome recorded
Phase 3 NCT06770114 Oct 2021 → May 2022 gingivitis Colgate Palmolive Completed No outcome recorded
Phase 437 trials · 3 missed
Phase 4 NCT07504250 Apr 2026 → Oct 2027 expected dacryocystitis All India Institute of Medical Sciences, Bhubaneswar Not yet recruiting No outcome recorded
Phase 4 NCT07376148 Nov 2025 → Feb 2026 overdue skin disorder Instituto de Oftalmología Fundación Conde de Valenciana Recruiting No outcome recorded
Phase 4 NCT07102186 Jul → Oct 2025 overdue acne Badr University Recruiting No outcome recorded
Phase 4 NCT07042581 Jun 2025 → Jun 2029 expected breast carcinoma in situ, hormone receptor-positive breast cancer Memorial Sloan Kettering Cancer Center Recruiting No outcome recorded
Phase 4 NCT06878599 May 2025 → Oct 2027 expected sudden sensorineural hearing loss Assiut University Not yet recruiting No outcome recorded
Phase 4 NCT06935877 Apr 2025 → Jun 2026 overdue bursitis Shin Kong Wu Ho-Su Memorial Hospital Not yet recruiting No outcome recorded
Phase 4 NCT06031493 Jan → Feb 2025 cervical cancer, sexual disorder Hospital Clinic of Barcelona Unknown No outcome recorded
Phase 4 NCT06694857 Oct 2024 → Nov 2025 — University of Pennsylvania Completed No outcome recorded
Phase 4 NCT05446402 Jun 2022 → May 2023 acne Northwestern University Completed No outcome recorded
Phase 4 NCT05834517 May → Dec 2022 periodontitis Ehab Haider Hassan El-emam Completed No outcome recorded
Phase not applicable66 trials · 2 met primary · 2 missed
— NCT07862686 Sep 2026 → Jul 2027 expected — Cairo University Not yet recruiting No outcome recorded
— NCT07666347 Jun → Dec 2026 expected osteoarthritis, knee Tanta University Recruiting No outcome recorded
— NCT07598253 Jun → Dec 2026 expected temporomandibular joint dysfunction syndrome Cairo University Not yet recruiting No outcome recorded
— NCT07548203 Apr → Sep 2026 overdue — Ain Shams University Recruiting No outcome recorded
— NCT07305519 Apr 2026 → Apr 2027 expected — University of Roma La Sapienza Recruiting No outcome recorded
— NCT07367087 Feb → Aug 2026 overdue — Nishtar Medical University Not yet recruiting No outcome recorded
— NCT07317856 Jan → Sep 2026 overdue — University of Baghdad Not yet recruiting No outcome recorded
— NCT07236632 Dec 2025 → Dec 2026 expected premature ejaculation Benha University Not yet recruiting No outcome recorded
— NCT07205640 Dec 2025 overdue dental caries Cairo University Not yet recruiting No outcome recorded
— NCT07495072 Nov 2025 → Dec 2026 expected cystitis, urinary bladder neoplasm BLAD-HYA Group Recruiting No outcome recorded
Comparator or background therapy105 trials
Phase 0 NCT06797960 Comparator Feb → Sep 2025 overdue osteoarthritis, knee Fayoum University Not yet recruiting No outcome recorded
Phase 0 NCT05034965 Comparator Oct 2021 → Oct 2022 — Alexandria University Unknown No outcome recorded
Phase 0 NCT03800810 Background May 2015 → May 2019 osteoarthritis, knee Indonesia University Unknown No outcome recorded
Phase 0 NCT04326985 Comparator Jan 2015 → Jan 2019 osteoarthritis, knee Chinese University of Hong Kong Completed No outcome recorded
Phase 1 NCT04893174 Background Sep 2022 → Sep 2024 osteoarthritis, knee Meridigen Biotech Co., Ltd. Unknown No outcome recorded

News releases announcing trial results or a regulatory action · 12

DateIssuerRelease
2025-11-05 Anika Therapeutics, Inc. Regulatory Anika Therapeutics Reports Filing of Final PMA Module for Hyalofast® Cartilage Repair Scaffold and Data from U.S. Pivotal FastTRACK Phase III Study anika.com ↗
On October 31, 2025, Anika submitted the third and final module of its Hyalofast PMA to the U.S. Food and Drug Administration (FDA).
2025-10-08 Merz Aesthetics Inc. Regulatory Merz Aesthetics Announces Submission of Premarket Approval Applications to the US FDA for Belotero® Volume Lidocaine and Belotero® Intense Lidocaine merzaesthetics.com ↗
Merz Aesthetics, the world’s largest dedicated medical aesthetics business, announced that it has submitted Premarket Approval (PMA) applications to the U.S. Food and Drug Administration (FDA) for Belotero® Volume Lidocaine and Belotero® Intense Lidocaine.
2025-07-30 Anika Therapeutics, Inc. Results Anika Reports Topline Results from U.S. Pivotal FastTRACK Phase III Study for Hyalofast® Cartilage Repair Scaffold and Provides Program Update anika.com ↗
Hyalofast consistently demonstrated improvements over microfracture, but missed on statistical significance of the pre-specified co-primary endpoints of percent change in KOOS Pain and IKDC function
2025-02-24 IBSA Institut Biochimique SA Results 10 years of Nahyco® technology celebrated at IMCAS 2025 ibsagroup.com ↗
Among these, Dr S. Liew presented clinical evidence highlighting the regenerative properties of hybrid cooperative complexes of hyaluronic acid: HCC treatment showed promising results in tissue repair, demonstrating a potential role in regenerative medicine 2 .
2023-08-17 Anika Therapeutics, Inc. Regulatory Anika Receives 510(k) Clearance for Integrity™ Implant System, a Regenerative Hyaluronic Acid-Based Patch System for Augmentation of Rotator Cuff Repairs anika.com ↗
Clearance of the hyaluronic acid (HA) based patch component joins the prior 510(k)s received for the associated fixation devices and instrumentation.
2023-07-05 Geistlich Pharma AG Results Geistlich expands its portfolio for the treatment of Periodontitis geistlich.com ↗
Compared to conventional treatments, the periodontal pockets closed and healed at a higher rate.
2023-06-12 Merz Aesthetics Inc. Results MERZ AESTHETICS ANNOUNCES POSITIVE RESULTS FROM PIVOTAL STUDY DEMONSTRATING EFFICACY AND SAFETY OF BELOTERO BALANCE® (+) FOR INFRAORBITAL HOLLOWS merzaesthetics.com ↗
Merz Aesthetics, the world’s largest dedicated medical aesthetics business, announced today topline results from a pivotal study demonstrating that Belotero Balance® (+) corrects volume loss in the infraorbital hollow area.
2022-03-31 Merz Aesthetics Inc. Results Merz Aesthetics to showcase new data at the 20th Aesthetics & Anti-Aging Medicine World Congress 2022 merzaesthetics.com ↗
The local tissue lifting capacity of dermal filler is greater with increasing hyaluronic acid concentration using an ex vivo human skin model.
2021-06-29 Galderma R&D Regulatory Galderma receives FDA approval for Restylane® Contour for cheek augmentation and correction of midface contour deficiencies galderma.com ↗
Galderma announced today the U.S. Food and Drug Administration (FDA) has approved Restylane® Contour for cheek augmentation and correction of midface contour deficiencies in adults over the age of 21.
2019-07-01 Teva Branded Pharmaceutical Products R&D, Inc. Regulatory Teva Announces Launch of 1% Sodium Hyaluronate in the United States tevapharm.com ↗
The product received approval from the Center for Devices and Radiological Health of the U.S. Food and Drug Administration.
2011-03-24 Seikagaku Corporation Regulatory Seikagaku announces U.S. FDA approval of Gel-One, a single injection Hyaluronic Acid injectable treatment for osteoarthritis pain of the knee. seikagaku.co.jp ↗
today announced that the U.S. Food and Drug Administration (FDA) approved Gel-One® (development code: Gel-200), a medical device for the treatment of pain in osteoarthritis of the knee, on March 22, 2011 (U.S. local time)
2009-09-28 Seikagaku Corporation Regulatory The application of SUPARTZ® was submitted to FDA for additional indication of treatment of pain associated with shoulder osteoarthritis seikagaku.co.jp ↗
The application of SUPARTZ® was submitted to FDA for additional indication of treatment of pain associated with shoulder osteoarthritis

All press releases naming this drug 20 releases

DateIssuerRelease

Evidence & citations 61 cited values

Every value below carries the sentence it was read from. 264 sources stand behind the page.

FieldValueCited text
Known as HYALURONIC ACID “30 drops of topical antioxidants (Gluconolactone 4%, Hyaluronic acid 0,01%, Allantoin 0,1%, Ferulic acid 3%, Acetyl heptapeptide 0,001%, Silver vine extract 1%, Ectoine 0,01%,...” NCT06170346 ↗
256

“Subjects who had received an injection of Cingal in the 13-01 study will receive a single 4 milliliter (mL) intra-articular injection of Cingal (88 milligrams Hyaluronic Acid...” NCT02381652 ↗

“This protocol presents a randomized clinical trial comparing Hyalone (hyaluronic acid) with calcium hydroxide as intracanal medicaments in mandibular first molars with necrotic...” NCT07821866 ↗

“The ERIPTO study seeks to study a proposed protocol utilizing various components of regenerative medicine including platelet rich plasma (PRP), hyaluronic acid (HA), and human...” NCT04222140 ↗

“Hyaluronic acid is currently used in periodontal regenerative surgery as a hydrogel mixture of cross-linked (1.6%) and natural (0.2%) HA of bacterial origin, marketed as...” NCT07581613 ↗

“combination cream consist of Triethyl citrate, Ethyl linoleate, GT peptide-10, Salicylic Acid 0,5%, Zinc Lactate, Hyaluronic acid will be given to subjects to be applied every...” NCT06775314 ↗

“Patients included in the study had been received 2 ml high molecular weight (1.476 x 106 average Daltons) hyaluronic acid with concentration of 22mg/ml (OPTIVISC UK hyaluronic...” NCT04188561 ↗

“Intra-Articular Injection is an injection of 3-6 milliliter (mL) hyaluronic acid (HA) mixed with 1 milliliter (mL) depo methylprednisolone (a steroid) and 2 mL 0.5% bupivacaine...” NCT04504812 ↗

“Participants will receive rexlemestrocel-L 2.0 mL injection of approximately 6 million rexlemestrocel-L cells in freeze media mixed in a 1:1 by-volume ratio with hyaluronic...” NCT06325566 ↗

“Cingal is a combination product consisting of 88 milligrams of cross-linked HA (hyaluronic acid) with 18 milligrams of TH (triamcinolone hexacetonide) in a 4 milliliter (mL)...” NCT03191903 ↗

“INTRODUCTION: To compare the efficacy and safety of a low-viscosity 0.3% hyaluronic acid (HA) ophthalmic solution with those of a comparator 0.3% HA formulation in patients...” PMID 41995979 ↗ Apr 2026

Show 246 more sources
Known as ACP gel “intrauterine application of auto-crosslinked hyaluronic acid (ACP) gel, after dilatation and curettage (D&C), reduces the incidence of intrauterine adhesions (IUAs)” PMID 28390688 ↗ Apr 2017
Known as Artibest “Patients in the experimental group received ultrasound-guided intra-articular injections of hyaluronic acid (Artibest, 60 mg/3 ml, 2%, manufactured by Kang Stem Biotech,...” NCT05983081 ↗
Known as ARTZDispo “five weekly intra-articular injections of 2.5 mL of hyaluronate sodium (ARTZDispo, Seikagaku Corporation Japan).” NCT02601170 ↗
Known as Belotero “combination, global facial and/or neck treatment with IncobotulinumA (Xeomin), HA (Belotero) and/or calcium hydroxyapatite (Radiesse+, Radiesse Classic).” NCT05039723 ↗
Known as Blad-Care “Hyaluronic Acid and Chondroitin Sulfate (Blad-Care™)” NCT07495072 ↗
Known as Durolane “one intraarticular injection of hyaluronan (HA) 3 ml (Durolane®, 20 mg/ml non-animal stabilized hyaluronic acid (NASHA) in buffered physiological sodium chloride solution pH 7...” NCT00731289 ↗
2

“Patients will receive an ultrasound-guided injection consisting of 3 ml hyaluronic acid (Durolane™) mixed with 40 mg triamcinolone (Kenalog™) into their hip joint.” NCT06653985 ↗

“Hyaluronic acid (Durolane)” NCT01586312 ↗
Known as EmbryoGlue “Hyaluronic Acid(EmbryoGlue®)” NCT06492785 ↗
Known as G2 medium “Hyaluronic Acid (G2 medium)” NCT06492785 ↗
Known as Gengiegel “hyaluronic acid (Gengiegel 0.2% oral gel )” NCT04390100 ↗
Known as Gengigel “The aim of the present study was to evaluate the clinical and microbial efficacy of local delivery of minocycline gel 2% and 0.2% hyaluronan gel (Gengigel) as an adjunctive...” NCT06997731 ↗
1

“Commercially available hyaluronic acid mouthrinse (Gengigel®, Ricerfarma, Milan, Italy).” NCT07689695 ↗
Known as Gengigel Oral Forte Gel “0.8% hyaluronic acid gel (Gengigel Oral Forte Gel, Ricefarma, Milan, Italy)” NCT07437885 ↗
Known as Gengigel Prof “0.8% polyvinylpyrrolidone sodium hyaluronate (HA) (Gengigel Prof, Ricerfarma SRL.) gel was impregnated on a sterile gelatin sponge” NCT06867055 ↗
Known as HA ClinicalTrials.gov intervention name — accepted as the source's own label NCT06797960 ↗
1

NCT02412735 ↗
Known as HA gel “For the Hyaluronic acid gel group: HA gel was injected 2-3mm apical to the coronal tip of the involved papillae” NCT05953896 ↗
Known as HANBIO BarriGel “patients undergoing thyroidectomy were randomized 1 : 1 : 1 to receive oxidized regenerated cellulose (Interceed™), high molecular weight hyaluronic acid (HANBIO BarriGel), or...” PMID 40613790 ↗ Jul 2025
Known as Healon 5 - hyaluronic acid 23mg/ml “Healon 5 - hyaluronic acid 23mg/ml” NCT00607685 ↗
Known as Hialid “0.3% hyaluronic acid eye drops (Hialid; Santen, Osaka, Japan) four times a day during the study, including the follow-up period.” NCT06034626 ↗
Known as high-molecular-weight Hyaluronic Acid “High-molecular-weight hyaluronic acid (HMWHA) plays a crucial role in immune tolerance at the maternal-fetal interface, promotes anti-inflammatory cytokine secretion, and...” NCT07305519 ↗
Known as HMWHA “High-molecular-weight hyaluronic acid (HMWHA) plays a crucial role in immune tolerance at the maternal-fetal interface, promotes anti-inflammatory cytokine secretion, and...” NCT07305519 ↗
Known as HYADENT BG “Hyaluronic acid is currently used in periodontal regenerative surgery as a hydrogel mixture of cross-linked (1.6%) and natural (0.2%) HA of bacterial origin, marketed as...” NCT07581613 ↗
1

“Hyaluronic Acid (HYADENT BG)” NCT04821804 ↗
Known as Hyajoint “a single HA injection (Hyajoint) weekly for 3 weeks” NCT04443166 ↗
Known as HyajointPlus “To compare the efficacy and structural change of intraarticular single platelet-rich plasma(PRP) versus novel crosslinked Hyaluronic Acid(HA)(HyajointPlus) for the treatment of...” NCT04972383 ↗
Known as Hyal One “This protocol presents a randomized clinical trial comparing Hyalone (hyaluronic acid) with calcium hydroxide as intracanal medicaments in mandibular first molars with necrotic...” NCT07821866 ↗
1

“Single intraarticular injection of Hyaluronic acid (Hyal One)” NCT02123368 ↗
Known as Hyalgan “intraarticular hyaluronic acid (20 mg/2 mL; Hyalgan, Fidia, Abano Terme, Italy) injections at the same intervals” NCT02958761 ↗