Clinical Efficacy of Local Delivery of Minocycline and Hyaluronan Gel to Treat Periodontitis in Diabetic Patients

Summary

The goal of this clinical trial is to investigate the local delivery of minocycline gel 2% and 0.2% hyaluronan gel to treat periodontitis in diabetic patients as adjunctive to subgingival instrumentation. The main question it aims to answer is: Does local use of minocycline gel and hyaluronan gel as an adjunct to SRP have resulted in significant additional improvement in the clinical conditions of stage II grade B periodontitis patients when compared with SRP alone?

Timeline

Start

2023-05-20

Primary completion

2025-01-01

Completion

2025-02-01

Publications

• ElHaddad SA, Alasfar AA, El-Shaglabow SA, Elgendy EA, Zahid MN, Abou-Seedou RM, Alzahrani HG. Local delivery of hyaluronan and minocycline as an adjunct to subgingival instrumentation in the treatment of stage II grade B diabetic periodontitis: a randomized split-mouth clinical and microbiological study. Clin Oral Investig. 2025 Nov 21;29(12):578. doi: 10.1007/s00784-025-06664-z.

Drugs

Indications