Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.

Phase 4 Completed 53 enrolled University of Valencia Regedent AG, Zürich · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of this study is to compare the effectiveness in periodontal regeneration of cross-linked hyaluronic acid at 1.8% (Hyadent BG®) with enamel matrix derivative (Emdogain®) in periodontal bone defects evaluating their clinical and radiographic variables.

Timeline

Start: 2020-03-01
Primary completion: 2024-09-30
Completion: 2024-12-30

Publications

Rodriguez-A M, Montiel-Company JM, Alpiste-Illueca F, Rodriguez-A L, Paredes-Gallardo V, Lopez-Roldan A. Comparision of crosslinked hyaluronic acid vs. enamel matrix derivative for periodontal regeneration: an 18-month follow-up randomized clinical trial. Clin Oral Investig. 2025 Mar 19;29(4):197. doi: 10.1007/s00784-025-06278-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hyaluronic Acid	Other / unclassified	3 ml	Other
Subject	Hyaluronic Acid	Other / unclassified	30 mg	Other
Comparator	enamel matrix derivative	Protein / enzyme biologic	—	Other

Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.

Summary

Timeline

Publications

Drugs

Indications