Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study

Summary

Clinical experience show limited effect of the drug Loperamide used to decrease output in stoma patients. Therefore the investigators see the need for a randomized blinded clinical trial to determine the effect of Loperamide opposite Placebo. Loperamide will be evaluated in relation to the following parameters * Change in ileostomy output in g/day in relation to oral intake * Quantification of the change in intestinal transit time using a radiopaque marker * The patient´s own assessment on which period they received Loperamide or Placebo

Timeline

Start

2014-10

Primary completion

2015-08

Completion

2015-08

Publications

• Kristensen K, Qvist N. The Acute Effect of Loperamide on Ileostomy Output: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study. Basic Clin Pharmacol Toxicol. 2017 Dec;121(6):493-498. doi: 10.1111/bcpt.12830. Epub 2017 Jul 10.

Drugs

Indications