Dexmedetomidine and Delirium in Patients After Cardiac Surgery

Summary

Postoperative delirium (POD) is a frequently occurring complication after cardiac surgery. Its occurrence is associated with worse outcomes of patients, including increased morbidity, prolonged hospital stay, increased medical cost, and higher mortality. It is also associated with long-term cognitive decline and decreased quality of life. However, until recently, pharmacological interventions that can effectively prevent its occurrence are still limited. The purpose of this study is to investigate whether perioperative dexmedetomidine use can decrease the incidence of postoperative delirium in patients undergoing cardiac surgery.

Timeline

Start

2014-11

Primary completion

2015-08

Completion

2015-11

Outcome

Missed primary endpoint

paper Dexmedetomidine did not decrease the incidence of delirium PMID 28182690 ↗

registry analysis (other test); DEX Group vs CTRL Group; p = 0.341; Odds Ratio (OR) 0.62 (95% CI 0.23 to 1.65); Regression, Logistic NCT02267538 ↗

Publications

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Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.1 ug/kg	Intravenous

Indications