drugset / Trial / NCT02292966

Impact of HCV Treatment on Neurocognitive Functions and Brain Metabolism

NCT02292966

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to examine whether neurocognitive impairments experienced by patients with chronic hepatitis C virus (HCV) infection can be reversed by treating HCV, with a new combination of direct acting antiviral drugs (daclatasvir (DCV), asunaprevir (ASV) and beclabuvir (BCV)). The study will assess the effect of HCV on the central nervous system (CNS) by assessing neurocognitive function and brain injury prior to treatment, and comparing it to the end of treatment, and 4, 12 and 24 weeks after treatment.

Timeline

Start
2015-07
Primary completion
2016-06
Completion
2016-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Asunaprevir Small molecule 200 mg Oral
Subject Beclabuvir Small molecule 75 mg Oral
Subject Daclatasvir Small molecule 30 mg Oral