Use of Warfarin After the First Trimester in Pregnant Women With APS

Phase 4 Unknown 100 enrolled Mohamed Sayed Abdelhafez

RandomizedParallel-groupOpen-labelPrevention

Summary

Evaluation of shifting to oral vitamin K antagonist after the first trimester instead of using low molecular weight heparin (LMWH) throughout pregnancy in pregnant women with antiphospholipid syndrome (APS)

Timeline

Start: 2014-11
Primary completion: 2024-12
Completion: 2025-06

Publications

Hamulyak EN, Scheres LJ, Marijnen MC, Goddijn M, Middeldorp S. Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss. Cochrane Database Syst Rev. 2020 May 2;5(5):CD012852. doi: 10.1002/14651858.CD012852.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Enoxaparin sodium	Other / unclassified	40 mg	Subcutaneous
Comparator	Warfarin	Small molecule	3 mg	Oral
Comparator	Warfarin	Small molecule	5 mg	Oral

Use of Warfarin After the First Trimester in Pregnant Women With APS

Summary

Timeline

Publications

Drugs

Indications