Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

Phase 2 Completed 50 enrolled Asan Medical Center

RandomizedParallel-groupTriple-blindTreatment

Summary

A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.

Timeline

Start: 2014-10
Primary completion: 2016-02
Completion: 2016-02

Outcome

Missed primary endpoint

paper However, no significant differences showed between sodium bicarbonate and placebo groups in sustained ROSC (4.0% vs. 16.0%, P=0.349) PMID 29850134 ↗

Publications

Ahn S, Kim YJ, Sohn CH, Seo DW, Lim KS, Donnino MW, Kim WY. Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study. J Thorac Dis. 2018 Apr;10(4):2295-2302. doi: 10.21037/jtd.2018.03.124.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	50 meq	Intravenous