Improving Fibrosis Outcomes With Metformin

Phase 2 Withdrawn Ottawa Hospital Research Institute CIHR Canadian HIV Trials Network · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This study will evaluate the role of Metformin on liver fibrosis in HCV-HIV co-infected and HCV mono-infected patients with insulin resistance receiving DAA HCV treatment.

Timeline

Start: 2016-01
Primary completion: 2017-09-30
Completion: 2018-04-03

Outcome

Outcome not reported

Stopped (Business): “insufficient funding”

Publications

Doyle MA, Singer J, Lee T, Muir M, Cooper C. Improving treatment and liver fibrosis outcomes with metformin in HCV-HIV co-infected and HCV mono-infected patients with insulin resistance: study protocol for a randomized controlled trial. Trials. 2016 Jul 20;17(1):331. doi: 10.1186/s13063-016-1454-6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	1 g	—