Pilot Study of the Effectiveness of Probiotics and Lactitol for the Decolonization of OXA-48 (Carbapenemase) Producing Klebsiella Pneumoniae Among Rectal Carriers

Phase 2 Unknown 20 enrolled Instituto de Investigación Hospital Universitario La Paz

NaSingle-groupOpen-labelTreatment

Summary

The combination of Lactitol and Probiotics (Lactobacillus acidophilus and Lactobacillus Biphidus) administered orally is an effective strategy of intestinal decolonization of Enterobacter produced OXA-48-type carbapenemase. The purpose of this study is to determine the effectiveness of Lactitol and Probiotics for the intestinal decolonization of people who carried Klebsiella pneumoniae produced OXA-48-type Carbapenemase.

Timeline

Start: 2014-10
Primary completion: 2015-10
Completion: 2015-10

Publications

Ramos-Ramos JC, Lazaro-Perona F, Arribas JR, Garcia-Rodriguez J, Mingorance J, Ruiz-Carrascoso G, Borobia AM, Pano-Pardo JR, Herruzo R, Arnalich F. Proof-of-concept trial of the combination of lactitol with Bifidobacterium bifidum and Lactobacillus acidophilus for the eradication of intestinal OXA-48-producing Enterobacteriaceae. Gut Pathog. 2020 Apr 7;12:15. doi: 10.1186/s13099-020-00354-9. eCollection 2020.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bifidobacterium bifidum	Unknown	1e+09 cells	Oral
Subject	Lactitol	Small molecule	10 g	Oral
Subject	Lactobacillus acidophilus	Other / unclassified	1e+09 cells	Oral

Indications

No indication recorded.