The Effect of Saxagliptin on Glucose Fluctuation and Immune Regulation in Patients With Type 1 Diabetes

Summary

To investigate whether saxagliptin could reduce the fluctuation of glycemia and improve the glycemic control in those type 1 diabetes through mechanisms of suppressing glucagon secretion, improving beta cell function, and re-regulating of the T cell immune system.

Timeline

Start

2014-11

Primary completion

2017-03

Completion

2017-03

Publications

• Shi Y, Shen M, Gu Y, Chen Y, Xu K, Hu J, Fang C, Guo H, Xu N, Wang G, Lu W, Tao S, Zhao S, Fang C, Ma J, Yan R, Sun R, Qian L, Wu C, Jiang H, Yang T. Heterogeneous effect of saxagliptin on glucose fluctuation and beta-cell function in T1DM: a multicentre, randomised trial. Nutr Diabetes. 2026 Mar 2;16(1):5. doi: 10.1038/s41387-026-00411-3.

Drugs

Indications