drugset / Trial / NCT02324777
Cannabinoid Profile Investigation of Vapourized Cannabis in Patients With Osteoarthritis of the Knee
Phase 2
Unknown
40 enrolled
Prairie Plant Systems Inc.
Algorithme Pharma Inc · collabDalhousie University · collabMcGill University Health Centre/Research Institute of the McGill University Health Centre · collabResearch Institute of the McGill University Health Center · collab
RandomizedCrossoverQuadruple-blindTreatment
Summary
Primary Objective: \- To determine the analgesic dose-response characteristics of vapourized cannabinoids with varying degrees of delta-9-tetrahydrocannabiol (THC)/ Cannabidiol (CBD) ratios. Secondary Objectives: * To compare functional changes and patient preferences of different cannabinoid (THC, CBD) profiles in patients with OA (Osteoarthritis); * To describe the Pharmacokinetics (PK) of vapourized cannabis of differing cannabinoid profiles in patients with OA; * To explore the short term safety of vapourized cannabis with different cannabinoid profiles. * To describe the incidence and severity of psychoactive events.
Timeline
- Start
- 2015-06
- Primary completion
- 2018-12
- Completion
- 2019-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cannabis | Traditional medicine (herbal / TCM) | 100 mg | Inhaled |