drugset / Trial / NCT02330120
Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics
RandomizedParallel-groupDouble-blindTreatment
Summary
The aim of this study is to compare the effects of dexmedetomidine and propofol on pulmonary mechanics in intensive care patients.
Timeline
- Start
- 2011-01
- Primary completion
- 2015-08
- Completion
- 2015-08
Publications
- Background Fernandes FC, Ferreira HC, Cagido VR, Carvalho GM, Pereira LS, Faffe DS, Zin WA, Rocco PR. Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats. Respir Physiol Neurobiol. 2006 Dec;154(3):342-50. doi: 10.1016/j.resp.2006.02.002. Epub 2006 Mar 9.
- Background Bang SR, Lee SE, Ahn HJ, Kim JA, Shin BS, Roe HJ, Sim WS. Comparison of respiratory mechanics between sevoflurane and propofol-remifentanil anesthesia for laparoscopic colectomy. Korean J Anesthesiol. 2014 Feb;66(2):131-5. doi: 10.4097/kjae.2014.66.2.131. Epub 2014 Feb 28.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | — |
| Comparator | Dexmedetomidine | Other / unclassified | 0.7 ug/kg | — |
| Subject | Propofol | Small molecule | 0.5 mg/kg | — |
| Subject | Propofol | Small molecule | 2 mg/kg | — |