RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure

Phase 4 Unknown 140 enrolled Beijing 302 Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

This study evaluates the Granulocyte colony-stimulating factor (G-CSF) in the treatment of Acute on Chronic Liver Failure in adult. Half participants will receive G-CSF and standard treatment in combination, while half participants will receive standard treatment.

Timeline

Start: 2013-10
Primary completion: 2016-04
Completion: 2016-10

Publications

Tong J, Wang H, Xu X, Wan Z, Fang H, Chen J, Mu X, Liu Z, Chen J, Su H, Liu X, Li C, Huang X, Hu J. Granulocyte Colony-Stimulating Factor Accelerates the Recovery of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Promoting M2-Like Transition of Monocytes. Front Immunol. 2022 May 16;13:885829. doi: 10.3389/fimmu.2022.885829. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Granulocyte colony-stimulating factor	Protein / enzyme biologic	5 ug/kg	Subcutaneous
Background	Ademetionine	Unknown	—	—
Background	Alprostadil	Unknown	—	—
Background	Glycyrrhizin	Unknown	—	—
Background	Human serum albumin	Protein / enzyme biologic	—	—
Background	Polyene Phosphatidylcholine	Small molecule	—	—
Background	reduced glutathione	Unknown	—	—

RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure

Summary

Timeline

Publications

Drugs

Indications