Drugs / Glycyrrhizin
last change Mar 2026 re-read 2 minutes ago

Glycyrrhizin

also known as Gly
Developed for
dental pulp necrosis · prostate cancer
Investigated by
Al-Azhar University · Mansoura University · University of Illinois at Chicago

Trials 3 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06291623 May 2022 → Dec 2023 dental pulp necrosis Mansoura University Completed No outcome recorded
Phase 21 trial
Phase 2 NCT06378346 Jul 2024 → Mar 2027 expected prostate cancer University of Illinois at Chicago Recruiting No outcome recorded
Phase not applicable1 trial
NCT07236567 Dec 2025 → Oct 2027 expected dental pulp necrosis Al-Azhar University Not yet recruiting No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT02651350 Background Dec 2015 → Jul 2019 drug-induced liver injury Beijing 302 Hospital Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06453304 Comparator Mar 2022 → Jun 2024 Mansoura University Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT02331745 Background Oct 2013 → Apr 2016 alcoholic liver disease, hepatitis B virus infection, liver failure Beijing 302 Hospital Unknown No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Glycyrrhizin Glycyrrhizin (an oleanane-type triterpenoid glucuronide), the main active and important constituent in licorice, is 50 times sweeter than sugar (29) and is used in large...” NCT06453304
5

“Standard treatment includes reduced glutathione, glycyrrhizin, ademetionine,polyene phosphatidylcholine, alprostadil, and human serum albumin) on the day of admission.” NCT02331745

“including reduced glutathione, glycyrrhizin, ademetionine, alprostadil,or ursodeoxycholic acid (UDCA)” NCT02651350

NCT07236567

NCT06291623

NCT06378346

Known as Gly “This study aimed to assess and compare the antibacterial effectiveness of glycyrrhizin (Gly) and calcium hydroxide (Ca(OH)2) as intracanal medicaments using molecular analysis.” PMID 41814304 Mar 2026
1

“one cycle of therapy consisting of Glycyrrhizin (GLY) (Observation, Dose Level 1 75mg daily, or Dose Level 2, 150mg daily) for 5 weeks (+/- 2 weeks) prior to surgery.” NCT06378346

Route Oral “75 mg orally daily” NCT06378346