Drugs / Glycyrrhizin
last change Mar 2026 re-read 9 days ago

Glycyrrhizin

also known as Gly
Developed for
dental pulp necrosis · prostate cancer
Investigated by
Al-Azhar University · Mansoura University · University of Illinois at Chicago

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial · 1 met primary
Phase 1 NCT06291623 May 2022 → Dec 2023 dental pulp necrosis Mansoura University Completed Met primary
Phase 21 trial
Phase 2 NCT06378346 Jul 2024 → Mar 2027 expected prostate cancer University of Illinois at Chicago Recruiting No outcome recorded
Phase not applicable1 trial
— NCT07236567 Dec 2025 → Oct 2027 expected dental pulp necrosis Al-Azhar University Not yet recruiting No outcome recorded
Comparator or background therapy3 trials
Phase 1/2 NCT02651350 Background Dec 2015 → Jul 2019 drug-induced liver injury Beijing 302 Hospital Completed Met primary
Phase 2/3 NCT06453304 Comparator Mar 2022 → Jun 2024 — Mansoura University Unknown No outcome recorded
Phase 4 NCT02331745 Background Oct 2013 → Apr 2016 alcoholic liver disease, hepatitis B virus infection, liver failure Beijing 302 Hospital Unknown No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Glycyrrhizin “Glycyrrhizin (an oleanane-type triterpenoid glucuronide), the main active and important constituent in licorice, is 50 times sweeter than sugar (29) and is used in large...” NCT06453304 ↗
5

“Standard treatment includes reduced glutathione, glycyrrhizin, ademetionine,polyene phosphatidylcholine, alprostadil, and human serum albumin) on the day of admission.” NCT02331745 ↗

“including reduced glutathione, glycyrrhizin, ademetionine, alprostadil,or ursodeoxycholic acid (UDCA)” NCT02651350 ↗

NCT07236567 ↗

NCT06291623 ↗

NCT06378346 ↗

Known as Gly “This study aimed to assess and compare the antibacterial effectiveness of glycyrrhizin (Gly) and calcium hydroxide (Ca(OH)2) as intracanal medicaments using molecular analysis.” PMID 41814304 ↗ Mar 2026
1

“one cycle of therapy consisting of Glycyrrhizin (GLY) (Observation, Dose Level 1 75mg daily, or Dose Level 2, 150mg daily) for 5 weeks (+/- 2 weeks) prior to surgery.” NCT06378346 ↗

Route Oral “75 mg orally daily” NCT06378346 ↗