Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Frozen Embryo Transfer on Cycle Outcomes

Phase 3 Completed 180 enrolled Royan Institute

RandomizedParallel-groupDouble-blindTreatment

Summary

The present study is designed as a pilot study with 150 patients in each group. Data collection form will be filled by the researcher who does not know the type of intervention in each group. Data analysis will be done through descriptive and perceptive statistical methods by using SPSS software version 20 for windows

Timeline

Start: 2014-10
Primary completion: 2018-12
Completion: 2018-12

Outcome

Missed primary endpoint

paper No significant difference was found in terms of clinical pregnancy among three groups. PMID 29626233 ↗

paper has no beneficial effect on pregnancy outcome and is not suggested. PMID 29626233 ↗

Publications

Hafezi M, Madani T, Arabipoor A, Zolfaghari Z, Sadeghi M, Ramezanali F. The effect of intrauterine human chorionic gonadotropin flushing on live birth rate after vitrified-warmed embryo transfer in programmed cycles: a randomized clinical trial. Arch Gynecol Obstet. 2018 Jun;297(6):1571-1576. doi: 10.1007/s00404-018-4752-2. Epub 2018 Apr 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	human chorionic gonadotropin	Protein / enzyme biologic	500 iu	Other