Neurokinin Receptor Antagonist Associated to Ondansetron in PONV

Phase 4 Completed 90 enrolled Cancer Institute of the State of São Paulo

RandomizedParallel-groupDouble-blindPrevention

Summary

The purpose of this study is to determine whether patients at high risk for postoperative nausea and vomiting can benefit from aprepitant, ondansetron and dexamethasone in the perioperative period.

Timeline

Start: 2015-02
Primary completion: 2015-08
Completion: 2015-08

Publications

Results Kawano H, Matsumoto T, Hamaguchi E, Manabe S, Nakagawa M, Yamada A, Fujimoto M, Tada F. Antiemetic efficacy of combined aprepitant and dexamethasone in patients at high-risk of postoperative nausea and vomiting from epidural fentanyl analgesia. Minerva Anestesiol. 2015 Apr;81(4):362-8. Epub 2014 Sep 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aprepitant	Other / unclassified	80 mg	Oral

Indications

No indication recorded.